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Transcription profiling by array of human natural killer cell lines, normal donors and clinical samples of natural killer cell neoplasms to detect tumor-specific genes

ABSTRACT: Comprehensive gene expression profiles of seven NK cell lines and eleven clinical samples of NK cell neoplasm were analyzed to detect tumor-specific genes. The gene expression profiles of NK cells from normal donor were analyzed as control samples.

ORGANISM(S): Homo sapiens

DISEASE(S): chronic active EB virus infection

SUBMITTER: Kennosuke Karube

PROVIDER: E-MEXP-2996 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses.

Karube Kennosuke K Nakagawa Masao M Tsuzuki Shinobu S Takeuchi Ichiro I Honma Keiichiro K Nakashima Yasuhiro Y Shimizu Norio N Ko Young-Hyeh YH Morishima Yasuo Y Ohshima Koichi K Nakamura Shigeo S Seto Masao M

Blood 20110620 12

Oligo-array comparative genomic hybridization (CGH) and gene-expression profiling of natural killer (NK)-cell neoplasms were used in an effort to delineate the molecular pathogenesis involved. Oligo-array CGH identified two 6q21 regions that were most frequently deleted (14 of 39 or 36%). One of these regions included POPDC3, PREP, PRDM1, ATG5, and AIM1, whereas the other included LACE1 and FOXO3. All genes located in these regions, except for POPDC3 and AIM1, were down-regulated in neoplastic s ...[more]

PMID: 21690554

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