Glucose depletion inhibits translation initiation in yeast - polysome and monosome profiling

ABSTRACT: This is a polysome/monosome profiling study on yeast undergoing glucose depletion. Polysomes and monosomes are extracted and the transcripts bound to each fraction are measured by microarray. The study reveals that glucose depletion inhibits translation initiation in a mechanism involving eIF4A loss and 48S pre-initiation complex accumulation, while the pentose phosphate pathway is co-ordinately up-regulated

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Leo Zeef 

PROVIDER: E-MEXP-3038 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress