Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Candida albicans wild type vs eed1 during RHE infection

ABSTRACT: Candida albicans wild type SC5314 and the eed1 delta mutant were used to infect reconstituted human oral epithelium (RHE) for 24h at 37°C and 5% CO2. Samples were taken 1h, 12h and 24h after infection. Total RNA was isolated, labeled with Cy5 and hybridised with a Cy3- labeled common reference.

ORGANISM(S): Candida albicans

SUBMITTER: Ronny Martin 

PROVIDER: E-MEXP-3085 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension.

Martin Ronny R   Moran Gary P GP   Jacobsen Ilse D ID   Heyken Antje A   Domey Jenny J   Sullivan Derek J DJ   Kurzai Oliver O   Hube Bernhard B  

PloS one 20110407 4

The extension of germ tubes into elongated hyphae by Candida albicans is essential for damage of host cells. The C. albicans-specific gene EED1 plays a crucial role in this extension and maintenance of filamentous growth. eed1Δ cells failed to extend germ tubes into long filaments and switched back to yeast growth after 3 h of incubation during growth on plastic surfaces. Expression of EED1 is regulated by the transcription factor Efg1 and ectopic overexpression of EED1 restored filamentation in  ...[more]

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