Transcription profiling of mammalian male germ cells undergoing mitotic growth, meiosis and gametogenesis in highly enriched cell populations

ABSTRACT: We report a comprehensive large-scale expression profiling analysis of mammalian male germ cells undergoing mitotic growth, meiosis and gametogenesis using High Density Oligonucleotide Microarrays and highly enriched cell populations. Among 11955 rat loci investigated, 1268 were identified as differentially transcribed in germ cells at subsequent developmental stages as compared to total testis, somatic Sertoli cells as well as brain and skeletal muscle controls. The loci were organized into four expression clusters that correspond to somatic, mitotic, meiotic and post-meiotic cell types. This work provides information about expression patterns of approximately 200 genes known to be important during male germ cell development. Approximately 40 of those are included in a group of 121 transc

ORGANISM(S): Rattus norvegicus

SUBMITTER: Michael Primig 

PROVIDER: E-MEXP-31 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress