HIV co-receptor usage determines specific miRNA modulations in T-lymphocytes.

ABSTRACT: HIV-1 and HIV-2 are two etiological agents of Acquired Immune Deficiency Syndrome (AIDS). Several differences exist between these two retroviruses in terms of geographical distribution, replication, transmission and progression to AIDS. The molecular reasons explaining these features are largely unknown. One reason could rely on host factors able to differently counteract HIV replication. Among these factors, cellular microRNAs (miRNAs) have recently emerged as playing crucial roles. One aspect of the complex interplay between HIV and host miRNAs is the ability of HIV-1 to modulate host miRNAs and thereby to create favorable conditions for its replication. Here, we sought to compare the miRNA modulations elicited by HIV-1 and HIV-2 using an unbiased experimental strategy based on miRNA arr

ORGANISM(S): Homo sapiens

SUBMITTER: Arnaud Muller 

PROVIDER: E-MEXP-3139 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress