Genomic studies of colorectal polyps and concurrent cancer

ABSTRACT: The well-known colorectal adenoma-carcinoma sequence suggests that a normal epithelial cell, through accumulations of genetic lesion and epigenetic disregulation can transform into a benign adenoma then further develop into a cancer. Using microarray-based comparative genomic hybridization (CGH), we reveal genome-wide copy number variations in colorectal cancer and polyp and use them to determine the tissueM-^Rs clonal relationship.

ORGANISM(S): Homo sapiens

DISEASE(S): colorectal polyp

SUBMITTER: Chian-Feng Chen 

PROVIDER: E-MEXP-3149 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress