Human Immunodeficiency Virus Tat Directly Interacts with a Specific Set of Cellular RNAs
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Richard Jenner
PROVIDER: E-MEXP-3199 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Human immunodeficiency virus Tat associates with a specific set of cellular RNAs.
Bouwman Russell D RD Palser Anne A Parry Chris M CM Coulter Eve E Rasaiyaah Jane J Kellam Paul P Jenner Richard G RG
Retrovirology 20140703
<h4>Background</h4>Human Immunodeficiency Virus 1 (HIV-1) exhibits a wide range of interactions with the host cell but whether viral proteins interact with cellular RNA is not clear. A candidate interacting factor is the trans-activator of transcription (Tat) protein. Tat is required for expression of virus genes but activates transcription through an unusual mechanism; binding to an RNA stem-loop, the transactivation response element (TAR), with the host elongation factor P-TEFb. HIV-1 Tat has ...[more]
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