Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human skin biopsies from individuals with a diagnosis of systemic sclerosis with diffuse scleroderma vs biopsies from normal individiduals


ABSTRACT: We used DNA microarrays to characterize gene expression patterns in skin biopsies from individuals with a diagnosis of systemic sclerosis with diffuse scleroderma and compared those to the patterns of gene expression seen in biopsies from normal, unaffected individuals.

ORGANISM(S): Homo sapiens

DISEASE(S): systemic sclerosis with diffuse scleroderma

SUBMITTER: Michael Whitfield 

PROVIDER: E-MEXP-32 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Systemic and cell type-specific gene expression patterns in scleroderma skin.

Whitfield Michael L ML   Finlay Deborah R DR   Murray John Isaac JI   Troyanskaya Olga G OG   Chi Jen-Tsan JT   Pergamenschikov Alexander A   McCalmont Timothy H TH   Brown Patrick O PO   Botstein David D   Connolly M Kari MK  

Proceedings of the National Academy of Sciences of the United States of America 20031006 21


We used DNA microarrays representing >12,000 human genes to characterize gene expression patterns in skin biopsies from individuals with a diagnosis of systemic sclerosis with diffuse scleroderma. We found consistent differences in the patterns of gene expression between skin biopsies from individuals with scleroderma and those from normal, unaffected individuals. The biopsies from affected individuals showed nearly indistinguishable patterns of gene expression in clinically affected and clinica  ...[more]

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