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Genomic profiling by SNParray of human angiosarcomas

ABSTRACT: Genomic signature of the ionizing radiation effect in angiosarcoma developed in the field of irradiation after radiotherapy

ORGANISM(S): Homo sapiens

SUBMITTER: Nabila Hadj-Hamou

PROVIDER: E-MEXP-3252 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A transcriptome signature of endothelial lymphatic cells coexists with the chronic oxidative stress signature in radiation-induced post-radiotherapy breast angiosarcomas.

Hadj-Hamou Nabila-Sandra NS Laé Marick M Almeida Anna A de la Grange Pierre P Kirova Youlia Y Sastre-Garau Xavier X Malfoy Bernard B

Carcinogenesis 20120424 7

Radiation-induced breast angiosarcomas are rare but recognized complication of breast cancer radiotherapy and are of poor prognosis. Little is known about the genetic abnormalities present in these secondary tumors. Herein, we investigated the differences in the genome and in the transcriptome that discriminate these tumors as a function of their etiology. Seven primary breast angiosarcomas and 18 secondary breast angiosarcomas arising in the irradiation field of a radiotherapy were analyzed. Co ...[more]

PMID: 22532251

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