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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse HoxA2 knockout

ABSTRACT: Transcription profiling was performed of second branchial arches of E11.5 embryos from Hoxa2+/- intercrosses. After genotyping the embryos, wild type and Hoxa2-/- were profiled by microarray.

ORGANISM(S): Mus musculus

SUBMITTER: Leo Zeef

PROVIDER: E-MEXP-3261 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide occupancy links Hoxa2 to Wnt-β-catenin signaling in mouse embryonic development.

Donaldson Ian J IJ Amin Shilu S Hensman James J JJ Kutejova Eva E Rattray Magnus M Lawrence Neil N Hayes Andrew A Ward Christopher M CM Bobola Nicoletta N

Nucleic acids research 20120105 9

The regulation of gene expression is central to developmental programs and largely depends on the binding of sequence-specific transcription factors with cis-regulatory elements in the genome. Hox transcription factors specify the spatial coordinates of the body axis in all animals with bilateral symmetry, but a detailed knowledge of their molecular function in instructing cell fates is lacking. Here, we used chromatin immunoprecipitation with massively parallel sequencing (ChIP-seq) to identify ...[more]

PMID: 22223247

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Single-cell transcriptomics of mouse wildtype and Hoxa2-/- pharyngeal arches 1 and 2 at E10.5.

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Microarray analysis of palatal shelves from wild-type versus p63-null mouse embryos

Project description:Mutations in the transcription factor p63 underlie of a series of human malformation syndromes which are defined by a combination of epidermal, limb and craniofacial abnormalities including cleft lip and palate. Transcription profiling was performed to determine the role of p63 in vivo mouse palatal shelves. Microarray analysis was done of palatal shelves dissected from E14.0 wild-type versus p63-null mouse embryos.

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