Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Genotyping of human colon cancer cell line SW613_3


ABSTRACT: Study of MYC extrachromosomal amplification in a colon cancer cell line by SNParray

ORGANISM(S): Homo sapiens

DISEASE(S): colorectal adenocarcinoma

SUBMITTER: Bernard Malfoy 

PROVIDER: E-MEXP-3277 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Characterization at nucleotide resolution of the homogeneously staining region sites of insertion in two cancer cell lines.

Gibaud Anne A   Vogt Nicolas N   Brison Olivier O   Debatisse Michelle M   Malfoy Bernard B  

Nucleic acids research 20130702 17


The mechanisms of formation of intrachromosomal amplifications in tumours are still poorly understood. By using quantitative polymerase chain reaction, DNA sequencing, chromosome walking, in situ hybridization on metaphase chromosomes and whole-genome analysis, we studied two cancer cell lines containing an MYC oncogene amplification with acquired copies ectopically inserted in rearranged chromosomes 17. These intrachromosomal amplifications result from the integration of extrachromosomal DNA mo  ...[more]

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