Dataset Information
Genotyping of human colon cancer cell line SW613_TU1
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): colorectal adenocarcinoma
SUBMITTER: Bernard Malfoy
PROVIDER: E-MEXP-3278 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Characterization at nucleotide resolution of the homogeneously staining region sites of insertion in two cancer cell lines.
Nucleic acids research 20130702 17
The mechanisms of formation of intrachromosomal amplifications in tumours are still poorly understood. By using quantitative polymerase chain reaction, DNA sequencing, chromosome walking, in situ hybridization on metaphase chromosomes and whole-genome analysis, we studied two cancer cell lines containing an MYC oncogene amplification with acquired copies ectopically inserted in rearranged chromosomes 17. These intrachromosomal amplifications result from the integration of extrachromosomal DNA mo ...[more]
