Unknown,Transcriptomics,Genomics,Proteomics

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Paredes_IPATIMUP_Comparison of cell lines derived from BT-20 cells using siRNA to silence E-cadherin and P-cadherin

ABSTRACT: Gene expression of four cell lines derived from BT-20 cells, namely, BT20 siCtr (E+/P+), BT20 siPcad (E+/P-), BT20 siEcad (E-/P+), and BT20 siEPcad (E-/P-) was compared using Agilent Human GE 4x44k v2 Microarrays and the Agilent One-Color Microarray-Based Gene Expression Analysis protocol (Quick Amp Labeling kit). Three independent biological samples were obtained for each cell line and BT20 siCtr (E+/P+) cells were used as control for data analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Laura Carreto 

PROVIDER: E-MEXP-3329 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

P-cadherin overexpression is associated with worse breast cancer survival, being a poor prognostic marker as well as a putative therapeutic target for the aggressive triple-negative and basal-like carcinomas (TNBCs). Previously, we have shown that P-cadherin promotes breast cancer invasion of cells where membrane E-cadherin was maintained; however, it suppresses invasion in models without endogenous cadherins, like melanomas. Here, we investigated if P-cadherin expression would interfere with th  ...[more]

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