MiR-223 Bone Marrow Derived Eosinophils
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Thomas Lu
PROVIDER: E-MEXP-3350 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MiR-223 deficiency increases eosinophil progenitor proliferation.
Lu Thomas X TX Lim Eun-Jin EJ Besse John A JA Itskovich Svetlana S Plassard Andrew J AJ Fulkerson Patricia C PC Aronow Bruce J BJ Rothenberg Marc E ME
Journal of immunology (Baltimore, Md. : 1950) 20130116 4
Recently, microRNAs have been shown to be involved in hematopoietic cell development, but their role in eosinophilopoiesis has not yet been described. In this article, we show that miR-223 is upregulated during eosinophil differentiation in an ex vivo bone marrow-derived eosinophil culture system. Targeted ablation of miR-223 leads to an increased proliferation of eosinophil progenitors. We found upregulation of a miR-223 target gene, IGF1R, in the eosinophil progenitor cultures derived from miR ...[more]
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