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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Microarray Analysis of Starvation Responses in Drosophila Larvae

ABSTRACT: Comparison of expression profiles

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Agnes Zvara

PROVIDER: E-MEXP-3352 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila.

Erdi Balázs B Nagy Péter P Zvara Agnes A Varga Agnes A Pircs Karolina K Ménesi Dalma D Puskás László G LG Juhász Gábor G

Autophagy 20120507 7

Autophagy delivers cytoplasmic material for lysosomal degradation in eukaryotic cells. Starvation induces high levels of autophagy to promote survival in the lack of nutrients. We compared genome-wide transcriptional profiles of fed and starved control, autophagy-deficient Atg7 and Atg1 null mutant Drosophila larvae to search for novel regulators of autophagy. Genes involved in catabolic processes including autophagy were transcriptionally upregulated in all cases. We also detected repression of ...[more]

PMID: 22562043

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