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Comparative genomic hybridization of variably invasive strains of Neisseria meningitidis

ABSTRACT: Genomic comparison of more and less invasive strains of Neisseria meningitidis

ORGANISM(S): Neisseria meningitidis

SUBMITTER: colin tinsley

PROVIDER: E-MEXP-343 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A chromosomally integrated bacteriophage in invasive meningococci.

Bille Emmanuelle E Zahar Jean-Ralph JR Perrin Agnes A Morelle Sandrine S Kriz Paula P Jolley Keith A KA Maiden Martin C J MC Dervin Catherine C Nassif Xavier X Tinsley Colin R CR

The Journal of experimental medicine 20050601 12

Cerebrospinal meningitis is a feared disease that can cause the death of a previously healthy individual within hours. Paradoxically, the causative agent, Neisseria meningitidis, is a common inhabitant of the human nasopharynx, and as such, may be considered a normal, commensal organism. Only in a small proportion of colonized people do the bacteria invade the bloodstream, from where they can cross the blood-brain barrier to cause meningitis. Furthermore, most meningococcal disease is caused by ...[more]

PMID: 15967821

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