IHF and HU gene expression in E coli K12

ABSTRACT: IHF and HU are two heterodimeric nucleoid associated proteins (NAP) that belong to the same protein family but interact differently with the DNA. IHF is a sequence-specific DNA-binding protein that bends the DNA by over 160o. HU is the most conserved NAP which binds non-specifically to duplex DNA with a particular preference for targeting nicked and bent DNA. Despite their importance, the in-vivo interactions of the two proteins to the DNA remain to be described at a high resolution and on a genome-wide scale. Further, the effects of these proteins on gene expression on a global scale remain contentious. Finally, the contrast between the functions of the homo- and heterodimeric forms of these proteins deserves the attention of further study. Here we present a genome-scale study of HU- and

ORGANISM(S): Escherichia coli

SUBMITTER: Aswin Seshasayee 

PROVIDER: E-MEXP-3461 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress