Exon-based transcriptome profiling of high-risk DLBCL patients less than 65 years old

ABSTRACT: The main purpose of the study was to identify biological prognostic factors that could be used to define poor risk diffuse large B-cell lymphoma (DLBCL) patients. We used exon array profiling to screen differentially expressed genes and splicing variants between clinically high risk patients, who have relapsed or remained in remission in response to dose dense chemoimmunotherapy. Study population consisted of 43 high-risk DLBCL/FL grade 3 patients less than 65 years old. The patients were treated in the Nordic phase II protocol with six courses of R-CHOEP14 followed by systemic central nervous system prophylaxis with one course of high dose methotrexate and one course of high dose cytarabine.

ORGANISM(S): Homo sapiens

SUBMITTER: Minna Taskinen 

PROVIDER: E-MEXP-3488 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress