Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Numb and numblike deleted by Nkx2.5Cre

ABSTRACT: The ventricular wall of the heart is composed of trabeculated and compactlayers, which are separated by yet unknown processes during embryonic development. Notch signaling plays important roles in cardiac development. Mutations in Notch signaling components are related to human congenital heart diseases Two homologues, Numb and Numblike (Numbl), are expressed in mammals, which also act as inhibitors of Notch signaling Here we investigate the role of Notch2 and Numb/Numblike during myocardial trabeculation and compaction. The aim of the experiment is to analyze whether Numb/Numblike are involved in inhibition of Notch activity in the developing heart.

ORGANISM(S): Mus musculus

SUBMITTER: Thomas Boettger 

PROVIDER: E-MEXP-3490 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

<h4>Aims</h4>The ventricular wall of the heart is composed of trabeculated and compact layers, which are separated by yet unknown processes during embryonic development. Here, we wanted to explore the role of Notch2 and Numb/Numblike for myocardial trabeculation and compaction.<h4>Methods and results</h4>We found that Notch2 activity is specifically down-regulated in the compact layer during cardiac development in the mouse. The biological role of Notch2 down-regulation was investigated by the e  ...[more]

Similar Datasets

Transcriptomics Transcription profiling by array of aMHC-Cre-mediated overexpression of N2ICD in mouse to analyze whether Numb/Numblike are involved in inhibition of Notch activity in the developing heart
2013-04-09 | E-MEXP-3661 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse heart from mice with a SMYD2 heart-specific deletion
2010-04-12 | E-MEXP-2542 | biostudies-arrayexpress
Transcriptomics Adult cardiomyocyte specific loss of myostatin
2014-05-16 | E-MEXP-3744 | biostudies-arrayexpress
Transcriptomics Cardiac mtDNA and oxidative stress
2013-11-01 | E-MEXP-3983 | biostudies-arrayexpress
Transcriptomics Transcription profiling by array of mouse kidney from Slc4a5 knock-out and wild type mice
2011-11-23 | E-MEXP-2692 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse kidney wild type and Slc4a11 knock-out
2010-03-03 | E-MEXP-2568 | biostudies-arrayexpress
Transcriptomics Analysis of miR-1_133a function
2013-11-15 | E-MEXP-3873 | biostudies-arrayexpress
Transcriptomics Regulation of NUMB alternative splicing by RBM5, RBM6 and RBM10 controls cancer cell proliferation (CLIP-Seq)
2013-12-20 | E-GEOD-48066 | biostudies-arrayexpress
Transcriptomics NIH3T3 transfected with myocardin
2013-11-15 | E-MEXP-3869 | biostudies-arrayexpress
Transcriptomics Rat heart developmental hypertrophy
2012-03-20 | E-MEXP-3590 | biostudies-arrayexpress