Vitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis

ABSTRACT: Hippocampal apoptosis is a characteristic feature of penumococcal meningitis associated with learning and memory deficitis as a sequel of the disease. We investigated the effect of vitamin B6 using an established infant rat model of experimental pneumococcal meningitis by histomorphology, transcriptomics and measurement of cellular nicotine amide adenine dinucleotide content. The data provides evidence that vitamin B6 is neuroprotecitve in terms of reduced hippocampal apoptosis involving reduction of the inflammatory response, preservation of cellular energy stores and up-regulated brain-derived neurotrophic factor levels.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Denise Burri 

PROVIDER: E-MEXP-3555 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress