Dataset Information
Transcription profiling of transgenic mice (tTA/IkappaBalpha-AA) treated with doxycycline (DOX), which represses expression of the transgenic IkappaBalpha
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Stephanie Pothion
PROVIDER: E-MEXP-358 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling.
Molecular and cellular biology 20060401 8
Synaptic activity-dependent de novo gene transcription is crucial for long-lasting neuronal plasticity and long-term memory. In a forebrain neuronal conditional NF-kappaB-deficient mouse model, we demonstrate here that the transcription factor NF-kappaB regulates spatial memory formation, synaptic transmission, and plasticity. Gene profiling experiments and analysis of regulatory regions identified the alpha catalytic subunit of protein kinase A (PKA), an essential memory regulator, as a new NF- ...[more]