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MiRNA Signatures Associate with Pathogenesis and Progression of Osteosarcoma

ABSTRACT: In order to investigate the genes differentially expressed between osteosarcoma and their normal bone counterpart we carried out class comparisons algorithms in BRB-ArrayTools with the paired t test.The CEL files were imported and robust multi-array averaging normalized. Genes whose expression differed by at least 1.5-fold from the median in at least 20% of the arrays were used.

ORGANISM(S): Homo sapiens

SUBMITTER: Marco Galasso

PROVIDER: E-MEXP-3628 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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miRNA signatures associate with pathogenesis and progression of osteosarcoma.

Jones Kevin B KB Salah Zaidoun Z Del Mare Sara S Galasso Marco M Gaudio Eugenio E Nuovo Gerard J GJ Lovat Francesca F LeBlanc Kimberly K Palatini Jeff J Randall R Lor RL Volinia Stefano S Stein Gary S GS Croce Carlo M CM Lian Jane B JB Aqeilan Rami I RI

Cancer research 20120220 7

Osteosarcoma remains a leading cause of cancer death in adolescents. Treatment paradigms and survival rates have not improved in two decades. Driving the lack of therapeutic inroads, the molecular etiology of osteosarcoma remains elusive. MicroRNAs (miRNAs) have demonstrated far-reaching effects on the cellular biology of development and cancer. Their role in osteosarcomagenesis remains largely unexplored. Here we identify for the first time an miRNA signature reflecting the pathogenesis of oste ...[more]

PMID: 22350417

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miRNA signatures associate with pathogenesis and progression of osteosarcoma.

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