Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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EMT


ABSTRACT: three pairs of isogenic human mammary epithelial and fibroblast cells, were used to characterized cell type specific dna methylation using using methyla cytosin immunoprecipitation

ORGANISM(S): Homo sapiens

SUBMITTER: Petr Novak 

PROVIDER: E-MEXP-3651 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Cell-type specific DNA methylation patterns define human breast cellular identity.

Novak Petr P   Stampfer Martha R MR   Munoz-Rodriguez Jose L JL   Garbe James C JC   Ehrich Mathias M   Futscher Bernard W BW   Jensen Taylor J TJ  

PloS one 20121220 12


DNA methylation plays a role in a variety of biological processes including embryonic development, imprinting, X-chromosome inactivation, and stem cell differentiation. Tissue specific differential methylation has also been well characterized. We sought to extend these studies to create a map of differential DNA methylation between different cell types derived from a single tissue. Using three pairs of isogenic human mammary epithelial and fibroblast cells, promoter region DNA methylation was ch  ...[more]

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