PKC1 cell cycle study

ABSTRACT: Transcriptional profiling of a Saccharomyces cerevisiae protein kinase Pkc1p temperature sensitive mutant on cells synchronised in S phase and then released. The Mcm1p-Fkh2p-Ndd1p complex in Saccharomyces cerevisiae controls the cyclical expression of the CLB2 cluster of genes at the G2/M phase transition. The activity of this complex is known to be positively controlled by cyclin-CDK and polo kinases. The current experiment aimed to demonstrate that the protein kinase Pkc1p works in the opposite manner to inhibit the activity of the Mcm1p-Fkh2p-Ndd1p complex and the expression of its target genes.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Leo Zeef 

PROVIDER: E-MEXP-3667 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress