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P19-atRA-kinetics

ABSTRACT: P19 embryonal carcinoma cells were treated with 1µM all trans retinoic acid and total RNA was collected at different time points

ORGANISM(S): Mus musculus

SUBMITTER: Philippe Lefebvre

PROVIDER: E-MEXP-3669 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors.

Flajollet Sébastien S Rachez Christophe C Ploton Maheul M Schulz Céline C Gallais Rozenn R Métivier Raphaël R Pawlak Michal M Leray Aymeric A Issulahi Al Amine AA Héliot Laurent L Staels Bart B Salbert Gilles G Lefebvre Philippe P

PloS one 20130610 6

Nuclear all-trans retinoic acid receptors (RARs) initiate early transcriptional events which engage pluripotent cells to differentiate into specific lineages. RAR-controlled transactivation depends mostly on agonist-induced structural transitions in RAR C-terminus (AF-2), thus bridging coactivators or corepressors to chromatin, hence controlling preinitiation complex assembly. However, the contribution of other domains of RAR to its overall transcriptional activity remains poorly defined. A prot ...[more]

PMID: 23762261

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