Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of Rattus norvegicus cardiomyocytes to investigate the effects of PD184352 and BI-D1870 on changes in expression induced by endothelin-1

ABSTRACT: Cardiomyocytes were exposed to PD184352, BI-D1870 or endothelin-1 alone, or to endothelin-1 in the presence of each inhibitor

ORGANISM(S): Rattus norvegicus

SUBMITTER: Angela Clerk 

PROVIDER: E-MEXP-3679 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists.

Amirak Emre E   Fuller Stephen J SJ   Sugden Peter H PH   Clerk Angela A  

The Biochemical journal 20130301 2

ERK1/2 (extracellular-signal-regulated kinase 1/2) and their substrates RSKs (p90 ribosomal S6 kinases) phosphorylate different transcription factors, contributing differentially to transcriptomic profiles. In cardiomyocytes ERK1/2 are required for >70% of the transcriptomic response to endothelin-1. In the present study we investigated the role of RSKs in the transcriptomic responses to the G(q)-protein-coupled receptor agonists endothelin-1, phenylephrine (a generic α(1)-adrenergic receptor ag  ...[more]

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