Transcription profiling by array of dendritic cells from three different human donors to characterize the impact of differential HIV opsonization on dendritic cell modulation

ABSTRACT: The aim of this study was to characterize the impact of differential HIV opsonization on DC modulation. DCs are the most potent antigen-presenting cells and among the first cells HIV is attaching to. HIV spontaneously activates the complement system even in the absence of specific antibodies and is therefore found opsonized with complement fragments from the beginning of infection. Gene expression profiles of DCs from three different human donors and treated for 24 hrs with 100 ng/ml LPS, 300 ng/ml non-opsonized HIV (HIV-MC), or 300 ng/ml complement-opsonized (HIV-C) were compared to those of untreated immature DCs.

ORGANISM(S): Homo sapiens

SUBMITTER: Hubert Hackl 

PROVIDER: E-MEXP-3706 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress