Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Hepatic transcriptomic profiles of mice exposed to dechlorane plus by gavage

ABSTRACT: Five-week-old male mice (Mus musculus, ICR) were exposed to dechlorane plus for 10 days. A total of tweenty-four mice were randomly assigned to control and three DP-treated groups. Six mice were applied in every group. For control group, corn oil was given to mice by gavage daily. For three DP-treated groups, mice received a daily dose of DP in corn oil at 500 mg DP /kg bw, 2000 mg DP /kg bw and 5000 mg DP /kg bw, respectively. After exposure, mice were anaesthetized under isoflurane followed by exsanguination. Livers were removed, and hepatic RAN for each mouse were immediately extract. The gene expression profiles for control and three DP-treated groups were determined by the GeneChip? Mouse Exon 1.0 ST arrays. the biological significances of differentially expressed genes (DEGs) were analyzed based on Molecule Annotation System 3.0 (MAS3.0, http://bioinfo.capitalbio.com/mas/). The microarray analysis of this study provide novel insight regarding toxicological effects and mechanism of DP at the transcriptome level

ORGANISM(S): Mus musculus

SUBMITTER: Bing Wu 

PROVIDER: E-MEXP-3707 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Responses of mouse liver to dechlorane plus exposure by integrative transcriptomic and metabonomic studies.

Wu Bing B   Liu Su S   Guo Xuechao X   Zhang Yan Y   Zhang Xuxiang X   Li Mei M   Cheng Shupei S  

Environmental science & technology 20120912 19

Dechlorane plus (DP), a chlorinated flame retardant, has been widely detected in different environmental matrices and biota. However, toxicity data for DP have seldom been reported. In the present study, we investigated hepatic oxidative stress, DNA damage, and transcriptomic and metabonomic responses of male mice administered 500 mg/kg, 2000 mg/kg, and 5000 mg/kg of DP by gavage for 10 days. The results showed that DP exposure increased the level of superoxide dismutase (SOD) and 8-hydroxy-2-de  ...[more]

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