Hepatic transcription profiling of mice exposed to As and Fe by drinking water

ABSTRACT: Five-week-old male mice (Mus musculus, ICR) were exposed to single As, single Fe and combined As and Fe for 90 days. A total of 40 mice were randomly assigned to control and three metal-treated groups. Nine mice were applied in every group. For control group, mice were fed with pure water. For three metal-treated groups, mice were feed with 3mg/L As, 5mg/L Fe and 3mg/L As + 5mg/L Fe, respectively. After exposure, mice were anaesthetized under isoflurane followed by exsanguination. Livers were removed, and hepatic RNA for each mouse was immediately extract. The gene expression profiles for control and three metal-treated groups were determined by the GeneChip Mouse Gene 1.0 ST arrays. Biological meanings of DEGs were analyzed by pathway analysis. DEGs were mapped to different biological pat

ORGANISM(S): Mus musculus

SUBMITTER: Bing Wu 

PROVIDER: E-MEXP-3763 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress