Dataset Information
Effect of Nur77 on gene expression in white adipose tissue of fasted mice.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hubert Hackl
PROVIDER: E-MEXP-3771 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Nr4a1 is required for fasting-induced down-regulation of Pparγ2 in white adipose tissue.
Molecular endocrinology (Baltimore, Md.) 20121218 1
Expression of the nuclear receptor gene, Nur77 (Nr4a1), is induced in white adipose tissue (WAT) in response to β-adrenergic stimulation and fasting. Recently, Nur77 has been shown to play a gene regulatory role in the fasting response of several other major metabolic tissues. Here we investigated the effects of Nur77 on the WAT transcriptome after fasting. For this purpose, we performed gene expression profiling of WAT from wild-type and Nur77(-/-) mice submitted to prolonged fasting. Results r ...[more]
