Unknown,Transcriptomics,Genomics,Proteomics

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IGF-I-induced chronic gliosis and retinal stress lead to neurodegeneration in an animal model of retinopathy


ABSTRACT: IGF-I exert multiple effects in different retinal cell populations in both physiological and pathological conditions. Transgenic mice overexpressing IGF-I in the retina showed impaired electroretinographic responses at 6-7 months of age that worsen with age. This retinal neuronal dysfunction was correlated with the loss of rod photoreceptors, bipolar, ganglion and amacrines cells. Neuronal alterations were preceded by the overexpression of retinal stress markers, acute phase proteins and gliosis-related genes. IGF-I overexpression leads to chronic gliosis and microgliosis in TgIGF-I retinas, with mild oxidative stress, impaired recycling of glutamate and defective potassium buffering. These impaired supportive functions can contribute to neurodegeneration in TgIGF-I retinas, together with the increased production of pro-inflammatory cytokines, potential mediators of neuronal death.

ORGANISM(S): Mus musculus

SUBMITTER: albert ribera 

PROVIDER: E-MEXP-3786 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage.

Casellas Alba A   Mallol Cristina C   Salavert Ariana A   Jimenez Veronica V   Garcia Miquel M   Agudo Judith J   Obach Mercè M   Haurigot Virginia V   Vilà Laia L   Molas Maria M   Lage Ricardo R   Morró Meritxell M   Casana Estefania E   Ruberte Jesús J   Bosch Fatima F  

The Journal of biological chemistry 20150513 27


The human insulin-like growth factor 2 (IGF2) and insulin genes are located within the same genomic region. Although human genomic studies have demonstrated associations between diabetes and the insulin/IGF2 locus or the IGF2 mRNA-binding protein 2 (IGF2BP2), the role of IGF2 in diabetes pathogenesis is not fully understood. We previously described that transgenic mice overexpressing IGF2 specifically in β-cells (Tg-IGF2) develop a pre-diabetic state. Here, we characterized the effects of IGF2 o  ...[more]

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