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Identification of pathways involved in lung carcinoid progression using gene expression profiling

ABSTRACT: Identification of differentially expressed genes between pulmonary carcinoid patients with a favorable and a poor disease outcome

ORGANISM(S): Homo sapiens

DISEASE(S): atypical lung carcinoid

SUBMITTER: Dorian Swarts

PROVIDER: E-MEXP-3790 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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CD44 and OTP are strong prognostic markers for pulmonary carcinoids.

Swarts Dorian R A DR Henfling Mieke E R ME Van Neste Leander L van Suylen Robert-Jan RJ Dingemans Anne-Marie C AM Dinjens Winand N M WN Haesevoets Annick A Rudelius Martina M Thunnissen Erik E Volante Marco M Van Criekinge Wim W van Engeland Manon M Ramaekers Frans C S FC Speel Ernst-Jan M EJ

Clinical cancer research : an official journal of the American Association for Cancer Research 20130226 8

<h4>Purpose</h4>Pulmonary carcinoids are well-differentiated neuroendocrine tumors showing usually a favorable prognosis. However, there is a risk for late recurrence and/or distant metastasis. Because histologic classification in typical and atypical carcinoids is difficult and its reliability to predict disease outcome varies, we evaluated three genes as potential prognostic markers, that is, orthopedia homeobox (OTP), CD44, and rearranged during transfection (RET).<h4>Experimental design</h4> ...[more]

PMID: 23444222

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