Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Everolimus

ABSTRACT: The effect of Everolimus (RAD001) on primary isolated human dermal microvascular endothelial (HDMVEC) and Fibroblast Cells as well as human glioblastoma brain tumor cell line (U87).

ORGANISM(S): Homo sapiens

SUBMITTER: christian schwager 

PROVIDER: E-MEXP-3802 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Deciphering the systems biology of mTOR inhibition by integrative transcriptome analysis.

Domhan Sophie S   Schwager Christian C   Wei Quanxiang Q   Muschal Stefan S   Sommerer Claudia C   Morath Christian C   Wick Wolfgang W   Maercker Christian C   Debus Jurgen J   Zeier Martin M   Huber Peter E PE   Abdollahi Amir A  

Current pharmaceutical design 20140101 1

The mTOR signaling plays an integral role in cellular homeostasis controlling the transition between the catabolic and anabolic states. Originally approved as immunosuppressive agents preventing allograft rejection, inhibitors of mTOR signaling have recently entered the arena of cancer therapy. Using rapamycin derivative (RAD001) as a prototype inhibitor, we aimed to systematically analyze the molecular mechanisms underlying the pleiotropic effects of mTOR signaling. Using proliferation- and clo  ...[more]

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