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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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BMT_aGvHD_Intestine

ABSTRACT: Mice received TBI and allogeneic bone marrow transplantation. One group without and one group with T cells. On day 14 after transplantation mice were sacrificed and the intestinal tract was isolated. RNA was isolated from the intestinal tract of the two experimental groups.

ORGANISM(S): Mus musculus

SUBMITTER: Dietmar Pfeifer

PROVIDER: E-MEXP-3807 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.

Leonhardt Franziska F Grundmann Sebastian S Behe Martin M Bluhm Franziska F Dumont Rebecca A RA Braun Friederike F Fani Melpomeni M Riesner Katarina K Prinz Gabriele G Hechinger Anne-Kathrin AK Gerlach Ulrike V UV Dierbach Heide H Penack Olaf O Schmitt-Gräff Annette A Finke Jürgen J Weber Wolfgang A WA Zeiser Robert R

Blood 20130117 17

Acute graft-versus-host disease (GvHD) is a complex process involving endothelial damage and neovascularization. Better understanding of the pathophysiology of neovascularization during GvHD could help to target this process while leaving T-cell function intact. Under ischemic conditions, neovascularization is regulated by different micro RNAs (miRs), which potentially play a role in inflamed hypoxic GvHD target organs. We observed strong neovascularization in the murine inflamed intestinal trac ...[more]

PMID: 23327924

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