Transcription profiling of Aedes infected with alphavirus, Sindbis (MRE16 Malaysian strain)

ABSTRACT: The midgut of hematophagous insects is the initial site of infection by arthropod-borne viruses (arboviruses) and plays a crucial role in vector competence. To further understand processes that occur in the midgut in response to infection by an arbovirus, DNA microarrays were used to analyze gene expression changes following infection by the alphavirus, Sindbis (MRE16 Malaysian strain). Midgut transcription profiles from mosquitoes fed blood containing 108 pfu/ml of virus were compared with those from mosquitoes ingesting blood meals having no virus. Transcription profiles from both experimental groups were analyzed at 1, 4, and 8 days post feeding. Among the many transcription changes observed by microarray analysis, the most dramatic involved three genes that had twenty-five to forty-fol

ORGANISM(S): Aedes aegypti

SUBMITTER: Sarjeet Gill 

PROVIDER: E-MEXP-381 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress