Molecular analysis of endocrine disruption in hornyhead turbot captured from wastewater treatment plant discharge locations in Southern California

ABSTRACT: Hornyhead turbot (Pleuronichthys verticalis) captured near sewage outfalls are used as sentinel fish for monitoring exposure to industrial and agricultural chemicals of ~20 million people living in coastal southern California. Although analyses of hormones in blood and organ morphology and histology in fish are useful for assessing exposure, there is a need for quantitative and sensitive molecular measurements, as many contaminants produce subtle effects. A novel multispecies microarray and qRT-PCR were used to investigate endocrine disruption in turbot captured near sewage outfalls in San Diego, Orange County and Los Angeles California. Analysis of expression of genes involved in hormone [e.g. estrogen, androgen, thyroid] responses and xenobiotic metabolism in turbot livers was correlate

ORGANISM(S): Pleuronichthys verticalis

SUBMITTER: Gary Hardiman 

PROVIDER: E-MEXP-3852 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress