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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of diagnostic tumoral samples in relation to primary response to drug treatment

ABSTRACT: Expression profile of diagnostic tumoral samples in relation to primary response to drug treatment

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Raquel Villuendas

PROVIDER: E-MEXP-388 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of genes involved in imatinib resistance in CML: a gene-expression profiling approach.

Villuendas R R Steegmann J L JL Pollán M M Tracey L L Granda A A Fernández-Ruiz E E Casado L F LF Martínez J J Martínez P P Lombardía L L Villalón L L Odriozola J J Piris M A MA

Leukemia 20060601 6

The use of the tyrosine kinase inhibitor imatinib, which blocks the enzymatic action of the BCR-ABL fusion protein, has represented a critical advance in chronic myeloid leukemia (CML) treatment. However, a subset of patients initially fails to respond to this treatment. Use of complementary DNA (cDNA) microarray expression profiling allows the identification of genes whose expression is associated with imatinib resistance. Thirty-two CML bone marrow samples, collected before imatinib treatment, ...[more]

PMID: 16598311

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Project description:Microarray technology was used to identify new predictive biomarkers in samples of clinically homogeneus patients.

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Project description:Identification of gene expression signatures associated with favourable or unfavourable treatment response and clinical outcome of Hodgkin lymphoma patients.

2006-06-01 | E-MEXP-507 | biostudies-arrayexpress

Transcription profiling of rat testis by transplacental exposure to estrogen receptor (ER) agonists - high and low doses of 17a-Ethynyl estradiol, genistein or bisphenol A

Project description:The purpose of this study was to determine 1) the transcriptional program elicited by exposure to three estrogen receptor (ER) agonists: 17 a-ethynyl estradiol (EE), genistein (Ges) and bisphenol A (BPA) during fetal development of the rat testis and epididymis; and 2) whether very low dosages of estrogens (evaluated over five orders of magnitude of dosage) produce unexpected changes in gene expression (i.e., a non-monotonic dose-response curve). In three independently conducted experiments, Sprague-Dawley rats were dosed (s.c.) with 0.001-10mg EE/kg/day, 0.001-100 mg Ges/kg/day or 0.002-400mg BPA/kg/day. While morphological changes in the developing reproductive system were not observed, the gene expression profile of target tissues were modified in a dose-responsive manner. Independent dose-response analyses of the three studies identified 56 genes that are significantly modified by EE, 28 genes by Ges and 15 genes by BPA (out of 8740). Even more genes were observed to be significantly changed when only the high dose is compared with all lower doses: 141, 46 and 67 genes, respectively. Global analyses aimed at detecting genes consistently modified by all of the chemicals identified 52 genes whose expression changed in the same direction across the three chemicals. The dose-response curve for gene expression changes was monotonic for each chemical, with both the number of genes significantly changed and the magnitude of change, for each gene, decreasing with decreasing dose. Using the available annotation of the gene expression changes induced by ER-agonist, our data suggest that a variety of cellular pathways are affected by estrogen exposure. These results indicate that gene expression data are diagnostic of mode of action and, if they are evaluated in the context of traditional toxicological end-points, can be used to elucidate dose-response characteristics.

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Transcription profiling of rat uterus after exposure to 17 alpha-ethynyl estradiol for different lengths of time

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2007-04-05 | E-MEXP-999 | biostudies-arrayexpress

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Transcription profiling of mouse MLL-CBP line to assess the immediate effects of induced MLL-CBP expression on hematopoiesis

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