Novel Genetic and Pharmacological Modulators of Copper Homeostasis

ABSTRACT: Copper (Cu) homeostasis is critical to the health of most organisms, and is thus tightly regulated by several highly conserved processes. Using the unique genomic tools available in yeast, we have expanded current knowledge of these processes by identifying 237 genes important for Cu-dependent growth. 116 of these genes, when deleted, decreased Cu-dependent respiratory growth. The remaining 121 genes, when deleted, produced respiratory growth defects that were specifically rescued by addition of Cu. Among the genes identified by our screen are known regulators of copper homeostasis, genes required to maintain low vacuolar pH, and genes where evidence supporting a functional link with Cu has been heretofore lacking. Many genes identified are not only conserved in man, but also associated wi

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Ulrich Schlecht 

PROVIDER: E-MEXP-3884 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress