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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome analysis of SIRT2 dependent genes modulated during infection by Listeria monocytogenes

ABSTRACT: tissue culture cells were treated with an inhibitor to the deacetylase SIRT2 (AGK2) and infected with Listeria monocytogenes

ORGANISM(S): Homo sapiens

SUBMITTER: guillaume soubigou

PROVIDER: E-MEXP-3912 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection.

Eskandarian Haig A HA Impens Francis F Nahori Marie-Anne MA Soubigou Guillaume G Coppée Jean-Yves JY Cossart Pascale P Hamon Mélanie A MA

Science (New York, N.Y.) 20130801 6145

Pathogens dramatically affect host cell transcription programs for their own profit during infection, but in most cases, the underlying mechanisms remain elusive. We found that during infection with the bacterium Listeria monocytogenes, the host deacetylase sirtuin 2 (SIRT2) translocates to the nucleus, in a manner dependent on the bacterial factor InlB. SIRT2 associates with the transcription start site of a subset of genes repressed during infection and deacetylates histone H3 on lysine 18 (H3 ...[more]

PMID: 23908241

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