Transcriptional changes in demyelinating canine distemper virus encephalitis

ABSTRACT: Canine distemper virus (CDV)-induced demyelinating leukoencephalitis (CDV-DL) in dogs is a translational animal model for human demyelinating diseases such as multiple sclerosis. The aim of this study was to perform an assumption-free microarray analysis of gene expression in different subgroups of CDV-DL as compared to normal controls. Dogs were classified into normal controls (group 1), acute CDV-DL lesions with CDV within the brain but without demyelination and inflammation (group 2), subacute lesions with demyelination but without inflammation (group 3), and subacute to chronic lesions with demyelination and inflammation (group 4).

ORGANISM(S): Canis familiaris

SUBMITTER: Reiner Ulrich 

PROVIDER: E-MEXP-3917 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress