Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: mike hubank
PROVIDER: E-MEXP-3922 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression.
Lakowski J J Han Y-T YT Pearson R A RA Gonzalez-Cordero A A West E L EL Gualdoni S S Barber A C AC Hubank M M Ali R R RR Sowden J C JC
Stem cells (Dayton, Ohio) 20110901 9
Retinal degenerative diseases are a major cause of untreatable blindness. Stem cell therapy to replace lost photoreceptors represents a feasible future treatment. We previously demonstrated that postmitotic photoreceptor precursors expressing an NrlGFP transgene integrate into the diseased retina and restore some light sensitivity. As genetic modification of precursor cells derived from stem cell cultures is not desirable for therapy, we have tested cell selection strategies using fluorochrome-c ...[more]
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