Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

12 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MiR-155 is protective of dietary non-alcoholic hepatosteatosis

ABSTRACT: We used microarrays to characterize the gene expression changes in liver caused by high fat diet feeding to C57BL/6 WT and miR-155-/- mice. Livers were collected from male mice at 24 weeks of age for RNA extraction and hybridization on Affymetrix mouse gene 1.0 ST array . We extracted RNA from 3 animals/group for microarray analysis (total N = 6 samples)

ORGANISM(S): Mus musculus

SUBMITTER: Ashley Miller

PROVIDER: E-MEXP-3932 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice.

Miller Ashley M AM Gilchrist Derek S DS Nijjar Jagtar J Araldi Elisa E Ramirez Cristina M CM Lavery Christopher A CA Fernández-Hernando Carlos C McInnes Iain B IB Kurowska-Stolarska Mariola M

PloS one 20130821 8

Hepatic steatosis is a global epidemic that is thought to contribute to the pathogenesis of type 2 diabetes. MicroRNAs (miRs) are regulators that can functionally integrate a range of metabolic and inflammatory pathways in liver. We aimed to investigate the functional role of miR-155 in hepatic steatosis. Male C57BL/6 wild-type (WT) and miR-155(-/-) mice were fed either normal chow or high fat diet (HFD) for 6 months then lipid levels, metabolic and inflammatory parameters were assessed in liver ...[more]

PMID: 23991091

Similar Datasets

transcriptome analysis of SIRT2 dependent genes modulated during infection by Listeria monocytogenes

Project description:tissue culture cells were treated with an inhibitor to the deacetylase SIRT2 (AGK2) and infected with Listeria monocytogenes

2013-06-01 | E-MEXP-3912 | biostudies-arrayexpress

MiR-34b regulates multiciliogenesis during organ formation in zebrafish

Project description:Multiciliated cells possess multiple motile cilia on the cell surface and are widely distributed throughout the vertebrate body to perform important physiological functions by regulating fluid movement in the intercellular space. However the molecular mechanisms underlying multiciliogenesis are not well understood. Although dysregulation of members of the miR-34 family plays a critical role in the progression of various cancers, the physiological function of miR-34b, especially in regulating multiciliogenesis, is largely unknown. Here we focus on the multiciliated cells in the zebrafish kidney to study whether and how miR-34b regulate multiciliogenesis. We performed genome-wide gene expression profiling of zebrafish kidney multiciliated cells in the absence (miR-34b morpholino) or presence of miR-34b (control morpholino). RNA samples for microarray gene expression profiling were collected at 3 days post fertilization.

2013-06-14 | E-MEXP-3893 | biostudies-arrayexpress

Transcriptional changes in demyelinating canine distemper virus encephalitis

Project description:Canine distemper virus (CDV)-induced demyelinating leukoencephalitis (CDV-DL) in dogs is a translational animal model for human demyelinating diseases such as multiple sclerosis. The aim of this study was to perform an assumption-free microarray analysis of gene expression in different subgroups of CDV-DL as compared to normal controls. Dogs were classified into normal controls (group 1), acute CDV-DL lesions with CDV within the brain but without demyelination and inflammation (group 2), subacute lesions with demyelination but without inflammation (group 3), and subacute to chronic lesions with demyelination and inflammation (group 4).

2014-04-23 | E-MEXP-3917 | biostudies-arrayexpress

Tracing the development of acute myeloid leukemia in CBL-syndrome

Project description:Comparison of copy number variations of acute myeloid leukemia mononuclear cells and the given cell types collected during complete remission of the acute myeloid leukemia

2014-02-12 | E-MEXP-3997 | biostudies-arrayexpress

Glucose regulation of root gravitropism in Arabidopsis thaliana

Project description:Comparison of root gravitropism upon glucose treatment as compared to control in Arabidopsis

2023-12-31 | E-MEXP-3887 | biostudies-arrayexpress

A Pre-clinical model of induction therapy and relapse in pediatric acute lymphoblastic leukemia

Project description:Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem. The current study used a pre-clinical model of induction therapy for pediatric ALL in NOD/SCID mice (Samuels et al Blood Cancer Journal (2014) 4, e232; doi:10.1038/bcj.2014.52) to study the development of drug resistance. We performed transcription profiling by array of human CD45-positive lymphocytes from patients with acute pediatric lymphoblastic leukemia, xenografted in NOD/SCID mice treated with vincristine, daunorubicin, dexamethasone and L-asparagine. Both the primary-patient-derived and xenograft cells were analysed. The VLXD2 treatment regime is described in full in the protocols associated with this submission and in Samuels et al (Blood Cancer Journal (2014) 4, e232; doi:10.1038/bcj.2014.52). This study is an extension of E-MEXP-3916.

2017-05-01 | E-MTAB-4759 | biostudies-arrayexpress

Zuklys etal_TECmRNA_DicerWT_vs_KO

Project description:mTEC and cTEC profiles from 2 week old Dicer fl/fl (WT) and Foxn1Cre::Dicer fl/fl mice. cTEC(CD45-EpCAM+MHCII+UEA-1-Ly51+) and mTEC(CD45-EpCAM+MHCII+UEA-1+Ly51-) were isolated from thymus tissue by cell sorting

2012-09-03 | E-MEXP-3303 | biostudies-arrayexpress

Serratia_infections

Project description:Transcriptional responses in the gut of the main malaria vector Anopheles gambiae following oral bacterial infection with the entomopathogen Serratia marcescens were identified using DNA microarrays. S. marcescens is a common member of the mosquito gut microbiota, found in both laboratory reared and field collected mosquitoes, that can be potentially pathogenic as in Drosophila (Nehme et al., 2007), while it has been shown to influence the outcome of Plasmodium infections (Bando et al., 2013). S. marcescens belongs to the Enterobacteriaceae family, members of which have been shown to influence malaria transmission dynamics (Cirimotich et al., 2011, Boissiere et al., 2012). To further investigate the interactions between S. marcescens and the mosquito host, likely to shape, directly or indirectly, malaria transmission dynamics, An. gambiae mosquitoes, from the recently established N'gousso M form laboratory colony that retains much of the genetic variation of field mosquitoes, were antibiotic treated for 5 days and subsequently orally infected with the Db11-GFP strain of S. marcescens. Bacteria-fed mosquitoes were selected 2 days post infection, and, 3 days post infection, guts from bacteria-fed mosquitoes were dissected. Uninfected control mosquitoes were treated in the same way. Differential expression in the gut of S. marcescens infected mosquitoes, compared to uninfected controls, was identified by hybridizing labelled complementary RNA, derived from total RNA extracted from the respective gut pools, in customized Agilent 4x44k gene expression microarrays, comprising oligonucleotide probes encompassing all An. gambiae annotated genes of the AgamP3.6 release, with each probe represented in duplicate.

2013-11-30 | E-MEXP-3952 | biostudies-arrayexpress

CD44 promotes stemness by enhancing hypoxia-inducible factor activity in the glioma perivascular niche

Project description:T98G cells treated (or not) with Doxycycline to induce expression of EGFP-CD44ICD in cells transfected with control or HIF2A siRNA.

2014-05-24 | E-MEXP-3914 | biostudies-arrayexpress

Transcriptome profiling of fgps1 mutant inflorescence stem

Project description:Total RNA was isolated from 35-d old inflorescence stems of plants. For microarray analysis, three biological replicates were included for both WT control and fpgs1 mutant.

2014-05-24 | E-MEXP-3915 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data