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Unknown,Transcriptomics,Genomics,Proteomics

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Comparison of gene expression in 40XY and 39XYO adult brain

ABSTRACT: 2 x 2 design, with 2 pooled total RNA samples (5 hemibrains per sample) per genotype (40,XY or 39,XY*O) hybridised to Mouse Gene 1.0 ST array to determine effect of genotype on brain gene expression

ORGANISM(S): Mus musculus

SUBMITTER: William Davies

PROVIDER: E-MEXP-3943 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder.

Trent Simon S Fry Jonathan P JP Ojarikre Obah A OA Davies William W

Molecular autism 20140306 1

<h4>Background</h4>The 39,XY*O mouse, which lacks the orthologues of the ADHD and autism candidate genes STS (steroid sulphatase) and ASMT (acetylserotonin O-methyltransferase), exhibits behavioural phenotypes relevant to developmental disorders. The neurobiology underlying these phenotypes is unclear, although there is evidence for serotonergic abnormalities in the striatum and hippocampus.<h4>Methods</h4>Using microarray and quantitative gene expression analyses, and gas chromatography-mass sp ...[more]

PMID: 24602487

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