Immunomodulatory Effects of Massage on Non-Perturbed Skeletal Muscle in Rats

ABSTRACT: Microarray was used as a screening tool to determine changes in gene transcription with cyclic compressive loading (CCL) (massage mimetic) applied at varying magnitudes in non-perturbed skeletal muscle. 24 male Wistar Rats were randomly assigned to one of three groups based on magnitude of load: Control: 0N; Low Load: 1.4N, and Moderate Load 4.5N. Animals were anesthetized using isofluorane, postioned lateral-recumbant with one limb secured to a platform with the Tibialis Anterior (TA) muscle facing superiorly. Using a custom CCL device, load was applied along the length of the TA cycled at 15mm proximally and distally at a frequency of 0.5Hz. Each animal received a 30-min bout of CCL once a day for four consecutive days. Rats were euthanized 24 hour following the fourth treatment. TA m

ORGANISM(S): Rattus norvegicus

SUBMITTER: Christine Waters-Banker 

PROVIDER: E-MEXP-3957 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress