Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways”

ABSTRACT: Two breast cancer cell lines, MCF-7 and MDA-MB-213, were treated progressively with docetaxel.

ORGANISM(S): Homo sapiens

SUBMITTER: David Westergaard 

PROVIDER: E-MEXP-3982 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways.

Hansen Stine Ninel SN   Westergaard David D   Thomsen Mathilde Borg Houlberg MB   Vistesen Mette M   Do Khoa Nguyen KN   Fogh Louise L   Belling Kirstine C KC   Wang Jun J   Yang Huanming H   Gupta Ramneek R   Ditzel Henrik J HJ   Moreira José J   Brünner Nils N   Stenvang Jan J   Schrohl Anne-Sofie AS  

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20150118 6

The microtubule-targeting taxanes are important in breast cancer therapy, but no predictive biomarkers have yet been identified with sufficient scientific evidence to allow clinical routine use. The purposes of the present study were to develop a cell-culture-based discovery platform for docetaxel resistance and thereby identify key molecular mechanisms and predictive molecular characteristics to docetaxel resistance. Two docetaxel-resistant cell lines, MCF7RES and MDARES, were generated from th  ...[more]

Similar Datasets

Transcriptomics Gene expression profile of corona radiata cells of individual MII oocytes developing into top quality embryos
2015-01-16 | E-MEXP-3985 | biostudies-arrayexpress
Transcriptomics Taxanes
2012-10-15 | E-MEXP-3391 | biostudies-arrayexpress
Transcriptomics Insulin Receptor-Overexpressing beta-Cells Ameliorate Hyperglycemia in Diabetic Rats through Wnt Signaling Activation
2013-06-11 | E-MEXP-3836 | biostudies-arrayexpress
Transcriptomics Exosomes mediate the cell-to-cell transmission of interferon alpha-induced antiviral activity_mRNA microarray
2013-05-17 | E-MEXP-3900 | biostudies-arrayexpress
Transcriptomics Operon Stromal upregulation of lateral epithelial adhesions
2011-01-01 | E-MEXP-2994 | biostudies-arrayexpress
Transcriptomics Transcription profiling of human gastric cancer cells after treatment with 5-aza-2-deoxycytidine and 4-phenylbutyric acid
2008-10-09 | E-MEXP-1821 | biostudies-arrayexpress
Transcriptomics Chromatin immunopreciptiation to identify thyroid hormone receptor beta-1 binding sites in mouse cerebellum
2009-04-03 | E-MEXP-1801 | biostudies-arrayexpress
Transcriptomics Affymetrix Stromal upregulation of lateral epithelial adhesions
2011-01-01 | E-MEXP-2990 | biostudies-arrayexpress
Transcriptomics Transcription profiling of Arabidopsis wild-type and atbzip60 mutant plants in response to the ER stress inducer tunicamycin
2008-11-19 | E-MEXP-1753 | biostudies-arrayexpress
Transcriptomics Alterations in tumour necrosis factor signaling pathways associated with cytotoxicity and resistance to taxanes in tumour cells.
2011-12-30 | E-GEOD-26129 | biostudies-arrayexpress