Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of human TK6 cells transduced with an oncoretrovirus expressing MDR1 (TK6MDR1) was vs untransduced TK6 cells and to TK6 cell transduced with an oncoretrovirus expressing the Neomycin resistance gene (TK6neo)

ABSTRACT: Gene expression of TK6 cells transduced with an oncoretrovirus expressing MDR1 (TK6MDR1) was compared to untransduced TK6 cells and to TK6 cell transduced with an oncoretrovirus expressing the Neomycin resistance gene (TK6neo). Two biological replicates of each were generated and the expression profiles were determined using Affymetrix Human Genome U133 Plus2.0 GeneChip microarrays. Comparisons between the sample groups allow the identification of genes with expression dependent on the MDR1 overexpression.

ORGANISM(S): Homo sapiens

SUBMITTER: Frederik Wenz 

PROVIDER: E-MEXP-428 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Overexpression of MDR1 using a retroviral vector differentially regulates genes involved in detoxification and apoptosis and confers radioprotection.

Maier Patrick P   Fleckenstein Katharina K   Li Li L   Laufs Stephanie S   Zeller W Jens WJ   Baum Christopher C   Fruehauf Stefan S   Herskind Carsten C   Wenz Frederik F  

Radiation research 20060901 3

Overexpression of P-glycoprotein (P-gp), the product of the MDR1 (multidrug resistance 1) gene, might complement chemotherapy and radiotherapy in the treatment of tumors. However, for safety and mechanistic reasons, it is important to know whether MDR1 overexpression influences the expression of other genes. Therefore, we analyzed differential gene expression in cells of the human lymphoblast cell line TK6 retrovirally transduced with MDR1 using the GeneChip Human Genome U133 Plus2.0 (Affymetrix  ...[more]

Similar Datasets

Transcriptomics Transcription profiling of human colon cells transduced with vector expressing thymosin beta4 antisense RNA are compared with empty vector-transduced cells
2010-09-01 | E-MEXP-2563 | biostudies-arrayexpress
Transcriptomics Transcriptome of double-positive thymocyte precursors transduced with a retrovirus encoding Lin28a
2012-02-17 | E-GEOD-34854 | biostudies-arrayexpress
Transcriptomics TK6 toxicogenomics reference database
2015-05-01 | E-GEOD-58431 | biostudies-arrayexpress
Transcriptomics TK6 toxicogenomics reference database
2015-05-01 | GSE58431 | GEO
Transcriptomics miRNA profiling of double-positive thymocytes transduced with a retrovirus encoding Lin28a compared to untransduced controls
2012-02-17 | E-GEOD-35081 | biostudies-arrayexpress
Genomics Affymetrix CytoScan array data for leukemia cell lines TK6 and WIL2-NS
2020-03-31 | GSE144446 | GEO
no omics defined Transcription profiling of mouse Deaf-1-transduced mammary epithelial cells
2008-10-25 | E-GEOD-12367 | biostudies-arrayexpress
Transcriptomics Soluble E-cadherin stimulated EcCAR-MSCs and UTD-MSCs with 3 normal donors
2024-04-01 | GSE256355 | GEO
Transcriptomics Transcription profiling by array of the effect of chemical mutagens and carcinogens on gene expression profiles in human TK6 cells
2012-06-04 | E-TABM-1223 | biostudies-arrayexpress
Transcriptomics RNA-seq profiling of human Tregs and conventional CD4+ cells that were left untransduced or transduced with a non-tonic signaling (CD19) or a tonic signaling (HA) CAR
2023-03-15 | GSE153384 | GEO