Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of E. coli LZ41 and LZ54 strains containing drug-resistant alleles of different topoisomerase genes treated with norfloxacin

ABSTRACT: Effect of FIS and H-NS on gene expression at relexed and hypernagative supercoiling level using LZ41 and LZ54 strains. LZ41 and LZ54 strains contain drug-resistant alleles of different topoisomerase genes. LZ41 strain treatment norfloxacin strongly relaxes DNA, whereas in LZ54 strain the same treatment generates high negative supercoiling (Khodursky et al., 1995, PNAS 92:11801-5; Ziechedrich et al, 1997, Genes Dev. 11:2580-92).

INSTRUMENT(S): ScanArray 6000 [Perkin Elmer]

ORGANISM(S): Escherichia coli

SUBMITTER: Georgi Muskhelishvili 

PROVIDER: E-MEXP-462 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Analog regulation of metabolic demand.

Sonnenschein Nikolaus N   Geertz Marcel M   Muskhelishvili Georgi G   Hütt Marc-Thorsten MT  

BMC systems biology 20110315

<h4>Background</h4>The 3D structure of the chromosome of the model organism Escherichia coli is one key component of its gene regulatory machinery. This type of regulation mediated by topological transitions of the chromosomal DNA can be thought of as an analog control, complementing the digital control, i.e. the network of regulation mediated by dedicated transcription factors. It is known that alterations in the superhelical density of chromosomal DNA lead to a rich pattern of differential exp  ...[more]

Similar Datasets

no omics defined Transcription profiling of E. coli LZ41 and LZ54 strains containing drug-resistant alleles of different topoisomerase genes treated with norfloxacin
2005-11-05 | E-MEXP-463 | biostudies-arrayexpress
Transcriptomics Transcription profiling of E. coli wild type and hns strains in rich dYT medium sampled in mid-exponential phase (ME), transition to stationary (TS) and late stationary phase (LS)
2005-10-31 | E-MEXP-464 | biostudies-arrayexpress
Transcriptomics Transcription profiling of E. coli CSH50 wild type and fis strains grown in dYT at 37 degrees C
2005-11-11 | E-MEXP-465 | biostudies-arrayexpress
Transcriptomics GM - E. coli - LZ fishns Act Rep
2011-01-07 | E-MEXP-3050 | biostudies-arrayexpress
Transcriptomics GM - E. coli - SetB LZ fishns Hyp Rel
2011-01-07 | E-MEXP-3049 | biostudies-arrayexpress
Transcriptomics Transcription profiling of E. coli wild type and fis or hns transcription factor mutants in CSH50, LZ41 and LZ54 strains during different growth phases, with relaxation and hypernegative supercoiling and after norflaxacin treatment
2013-01-30 | E-TABM-86 | biostudies-arrayexpress
Transcriptomics Transcription profiling of E. coli W3110 wild type and rpoZ mutant cells to distinguish between the genes expressed either in the presence or absence of RNA polymerase omega subunit during log phase
2007-08-01 | E-MEXP-942 | biostudies-arrayexpress
Transcriptomics Transcription profiling of E. coli CSH50 wild type and hupA::cm hupB::kan double mutant cells
2008-12-01 | E-MEXP-1742 | biostudies-arrayexpress
Transcriptomics Transcription profiling of stationary phase E.coli wild type and crl::cat mutant strains to identify Crl-regulated genes
2007-01-01 | E-MEXP-720 | biostudies-arrayexpress
Transcriptomics Transcription profiling of wild type and lon knock-out E. coli in M9 media at log phase
2008-06-10 | E-MEXP-1484 | biostudies-arrayexpress