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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse comparing homozygous Tslc1 knock out mouse to matched control animals

ABSTRACT: Testis transcription profiling experiment comparing homozygous Tslc1 to matched control animals. Two animals were pooled for each sample, and four technical replicate hybridisations carried out (one dye swapped).

INSTRUMENT(S): Scanning hardware

ORGANISM(S): Mus musculus

DISEASE(S): normal

SUBMITTER: Peter Ellis

PROVIDER: E-MEXP-478 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis.

van der Weyden Louise L Arends Mark J MJ Chausiaux Oriane E OE Ellis Peter J PJ Lange Ulrike C UC Surani M Azim MA Affara Nabeel N Murakami Yoshinori Y Adams David J DJ Bradley Allan A

Molecular and cellular biology 20060501 9

Tumor suppressor of lung cancer 1 (TSLC1), also known as SgIGSF, IGSF4, and SynCAM, is strongly expressed in spermatogenic cells undergoing the early and late phases of spermatogenesis (spermatogonia to zygotene spermatocytes and elongating spermatids to spermiation). Using embryonic stem cell technology to generate a null mutation of Tslc1 in mice, we found that Tslc1 null male mice were infertile. Tslc1 null adult testes showed that spermatogenesis had arrested at the spermatid stage, with deg ...[more]

PMID: 16611999

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