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Transcription profiling of diabetic neuropathy in dorsal root ganglia from streptozotocin-diabetic male wistar rats over the first 8 weeks of diabetes

ABSTRACT: A study of diabetic neuropathy in dorsal root ganglia from streptozotocin-diabetic male wistar rats over the first 8 weeks of diabetes

ORGANISM(S): Rattus norvegicus

SUBMITTER: Leanne Wardleworth

PROVIDER: E-MEXP-515 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of changes in gene expression in dorsal root ganglia in diabetic neuropathy: correlation with functional deficits.

Price Sally Amanda SA Zeef Leo Arnoldus Hendrikus LA Wardleworth Leanne L Hayes Andrew A Tomlinson David Richard DR

Journal of neuropathology and experimental neurology 20060701 7

This study aimed to correlate the onset of functional deficits in diabetic neuropathy with changes in gene expression in rat dorsal root ganglia (DRG). After 1, 4, or 8 weeks of streptozotocin-induced diabetes, sensory and motor nerve conduction velocities (NCV) were measured as an indicator of neuropathy and changes in gene expression were measured using Affymetrix oligonucleotide microarrays. No significant changes in NCV were found after 1 week of diabetes, but after 4 and 8 weeks, there was ...[more]

PMID: 16825959

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