E-MEXP-562 - Transcription profiling of nude mice tumor biopsies generated by the injection of mesenchymal stem cells (MSC) - OmicsDI

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of nude mice tumor biopsies generated by the injection of mesenchymal stem cells (MSC)

ABSTRACT: Transformed MSC were injected subcutaneously into the flank of athymic CD1 nude mice (C/River). Biopsies of 1.5 cm spindle cell tumours were taken.

ORGANISM(S): Homo sapiens

SUBMITTER: Stephen Henderson

PROVIDER: E-MEXP-562 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production.

Funes Juan M JM Quintero Marisol M Henderson Stephen S Martinez Dolores D Qureshi Uzma U Westwood Claire C Clements Mark O MO Bourboulia Dimitra D Pedley R Barbara RB Moncada Salvador S Boshoff Chris C

Proceedings of the National Academy of Sciences of the United States of America 20070323 15

An increased dependency on glycolysis for ATP production is considered to be a hallmark of tumor cells. Whether this increase in glycolytic activity is due mainly to inherent metabolic alterations or to the hypoxic microenvironment remains controversial. Here we have transformed human adult mesenchymal stem cells (MSC) using genetic alterations as described for differentiated cells. Our data suggest that MSC require disruption of the same pathways as have been shown for differentiated cells to c ...[more]

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